The Girl With Uneven Pupils

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Sanya, 14, came in after her teacher noticed her pupils were unequal. Her parents hadn’t observed any issues—no headaches, no trauma, no visual complaints. Her right pupil was larger, reacting sluggishly to light but briskly to accommodation.

I suspected Adie’s tonic pupil. Though benign, I checked for Holmes-Adie syndrome and ruled out other neurologic issues.

When her aunt visited a month later, she was stunned—she too had anisocoria and never knew it had a name.


The Lesson Learned

Not all anisocoria is an emergency. Knowing benign causes is as vital as recognizing urgent ones.

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